GlutaredoxinV1, Main, Exploration, bibRecord, 000918

S-glutathiolation in life and death decisions of the cell.

Identifieur interne : 000918 ( Main/Exploration ); précédent : 000917; suivant : 000919

S-glutathiolation in life and death decisions of the cell.

Auteurs : Isabella Dalle-Donne [Italie] ; Graziano Colombo ; Nicoletta Gagliano ; Roberto Colombo ; Daniela Giustarini ; Ranieri Rossi ; Aldo Milzani

Source :

Free radical research [ 1029-2470 ] ; 2011.

RBID : pubmed:20815784

Descripteurs français

KwdFr :
- Apoptose (physiologie), Glutathion (métabolisme), Humains (MeSH), Mort cellulaire (physiologie), Oxydoréduction (MeSH), Protéines (métabolisme), Transduction du signal (MeSH).
MESH :
- métabolisme : Glutathion, Protéines.
- physiologie : Apoptose, Mort cellulaire.
- Humains, Oxydoréduction, Transduction du signal.

English descriptors

KwdEn :
- Apoptosis (physiology), Cell Death (physiology), Glutathione (metabolism), Humans (MeSH), Oxidation-Reduction (MeSH), Proteins (metabolism), Signal Transduction (MeSH).
MESH :
- chemical , metabolism : Glutathione, Proteins.
- physiology : Apoptosis, Cell Death.
- Humans, Oxidation-Reduction, Signal Transduction.

Abstract

Reversible S-glutathiolation of specific proteins at sensitive cysteines provides a powerful mechanism for the dynamic, post-translational regulation of many cellular processes, including apoptosis. Critical in ascribing any regulatory function to S-glutathiolation is its reversibility, mainly regulated by glutaredoxins. Apoptosis is a controlled form of cell death that plays fundamental roles during embryonic development, tissue homeostasis and some diseases. Much of what happens during the demolition phase of apoptosis is orchestrated primarily by caspases, the final executioners of cell death. Recent findings support an essential role for S-glutathiolation in apoptosis, often at the level of caspases or their inactive precursors, and several studies have demonstrated the importance of glutaredoxins in protecting against apoptosis. These observations have contributed to recent advances in apoptosis research. However, the effective relevance of protein S-glutathiolation and the precise molecular targets in apoptotic signalling remain unresolved and a key challenge for future research.

DOI: 10.3109/10715762.2010.515217
PubMed: 20815784

Affiliations:

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Le document en format XML

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<term>Cell Death (physiology)</term>
<term>Glutathione (metabolism)</term>
<term>Humans (MeSH)</term>
<term>Oxidation-Reduction (MeSH)</term>
<term>Proteins (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
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<term>Glutathion (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Mort cellulaire (physiologie)</term>
<term>Oxydoréduction (MeSH)</term>
<term>Protéines (métabolisme)</term>
<term>Transduction du signal (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glutathione</term>
<term>Proteins</term>
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<term>Cell Death</term>
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<term>Oxidation-Reduction</term>
<term>Signal Transduction</term>
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<front><div type="abstract" xml:lang="en">Reversible S-glutathiolation of specific proteins at sensitive cysteines provides a powerful mechanism for the dynamic, post-translational regulation of many cellular processes, including apoptosis. Critical in ascribing any regulatory function to S-glutathiolation is its reversibility, mainly regulated by glutaredoxins. Apoptosis is a controlled form of cell death that plays fundamental roles during embryonic development, tissue homeostasis and some diseases. Much of what happens during the demolition phase of apoptosis is orchestrated primarily by caspases, the final executioners of cell death. Recent findings support an essential role for S-glutathiolation in apoptosis, often at the level of caspases or their inactive precursors, and several studies have demonstrated the importance of glutaredoxins in protecting against apoptosis. These observations have contributed to recent advances in apoptosis research. However, the effective relevance of protein S-glutathiolation and the precise molecular targets in apoptotic signalling remain unresolved and a key challenge for future research.</div>
</front>
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<Title>Free radical research</Title>
<ISOAbbreviation>Free Radic Res</ISOAbbreviation>
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<ArticleTitle>S-glutathiolation in life and death decisions of the cell.</ArticleTitle>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dalle-Donne</LastName>
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<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
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<name sortKey="Gagliano, Nicoletta" sort="Gagliano, Nicoletta" uniqKey="Gagliano N" first="Nicoletta" last="Gagliano">Nicoletta Gagliano</name>
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<country name="Italie"><region name="Lombardie"><name sortKey="Dalle Donne, Isabella" sort="Dalle Donne, Isabella" uniqKey="Dalle Donne I" first="Isabella" last="Dalle-Donne">Isabella Dalle-Donne</name>
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	Serveur d'exploration sur la glutarédoxine
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Serveur d'exploration sur la glutarédoxine

S-glutathiolation in life and death decisions of the cell.

S-glutathiolation in life and death decisions of the cell.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki